Impact of Timing and Dose of Isosorbide dinitrate Administration on Coronary MRI
نویسندگان
چکیده
Introduction Despite technical progress, coronary magnetic resonance imaging (MRI) still faces multiple challenges including low SNR and small vessel size. Coronary vasodilators, such as sublingual nitroglycerin (NTG) or longer acting nitrates (e.g., isosorbide dinitrate), are commonly used to study coronary circulation. Terashima et al. [1] reported on the impact of sublingual NTG on coronary MRI. Isosorbide dinitrate (Isordil) has been previously reported in a multi-center clinical coronary MRI trial [2]; however no data have been provided to quantify coronary MRI image quality improvement and time course of the effect of isosorbide dinitrate. In this study, we investigated the impact of sublingual isosorbide dinitrate administration on SNR, vessel diameter, vessel sharpness and overall image quality in coronary MRI as a function of time, dose and imaging sequence.
منابع مشابه
Coronary MR imaging: effect of timing and dose of isosorbide dinitrate administration.
PURPOSE To quantify the effect of sublingual isosorbide dinitrate (ISDN) administration on coronary magnetic resonance (MR) imaging. MATERIALS AND METHODS Written informed consent was obtained from all participants, and the HIPAA-compliant protocol was approved by the Institutional Review Board. Coronary MR imaging was performed at 1.5 T before and after administration of ISDN (2.5 or 5 mg) i...
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